Fluorine and fluoronomics
There are so far only a few natural organofluorine compounds known, but there are hundreds of man-made organofluorine compounds (mainly perfluorinated compounds (PFCs)) known. Beside the widely known use in Teflon and other plastics fluorinated groups are also often used in drugs to influence their physiological retention.
These man-made compounds are bioaccumulating in fatty tissue and can have detrimental health effects. There is still relatively little known about the metabolism of fluorinated compounds. The main reason for this is the difficulty to identify unknown fluorinated compounds. Fluorinated compounds are difficult to distinguish from non-fluorinated compounds by organic mass spectrometry and normally not detectable by elemental detectors either.
We are working on new methods for fluorine detection using ICP-MS as fluorine specific detector through the formation of polyatomic ions, which could be a potential method for unknown fluorine compound detection. Another method applied is molecular absorption spectrometry determining fluorine as polyatomic molecule. Additionally we use combustion ion-chromatography for the detection of fluorinated compounds after fractionation of samples. The PhDs working in this general field are at the moment concentrating on developing the methods and testing their robustness. Experiments are also ongoing to couple these methods on- or off-line to HPLC and other separation methods.
The aim of this research is:
- to enable the sensitive and efficient quantification of unknown fluorinated compounds for example metabolic products of fluorinated drugs.
- to support identification of unknown compounds by the combination HPLC-ICP-MS and ESI-MS.
- to elucidate metabolic pathways of organofluorine compounds.
Jörg FeldmannInstitut für Chemie
Institut für Chemie
Elisabeth Jenewein-Fleischer (morning) Claudia Fritz (afternoon)
Institut für Chemie